BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine
نویسندگان
چکیده
منابع مشابه
Resistance pathways of human immunodeficiency virus type 1 against the combination of zidovudine and lamivudine.
A better understanding of human immunodeficiency virus type 1 drug-resistance evolution under the selective pressure of combination treatment is important for the design of long-term effective treatment strategies. We applied Bayesian network learning to sequences from patients treated with the reverse transcriptase inhibitor combination of zidovudine (AZT) and lamivudine (3TC) to identify the ...
متن کاملCombination treatment with zidovudine, didanosine, and nevirapine in infants with human immunodeficiency virus type 1 infection.
BACKGROUND In infants and children with maternally acquired human immunodeficiency virus type 1 (HIV-1) infection, treatment with a single antiretroviral agent has limited efficacy. We evaluated the safety and efficacy of a three-drug regimen in a small group of maternally infected infants. METHODS Zidovudine, didanosine, and nevirapine were administered in combination orally to eight infants...
متن کاملInhibition of purified recombinant reverse transcriptase from wild-type and zidovudine-resistant clinical isolates of human immunodeficiency virus type 1 by zidovudine, stavudine, and lamivudine triphosphates.
Cross-resistance between zidovudine, stavudine, and lamivudine was studied, using purified recombinant reverse transcriptase from a zidovudine-susceptible and -resistant pair of clinical isolates of human immunodeficiency virus type 1. The zidovudine-resistant isolate exhibited low-level cross-resistance to both stavudine and lamivudine in drug susceptibility assays. Enzyme from the resistant i...
متن کاملDisposition of zidovudine in obese pregnant women with human immunodeficiency virus type 1 infection.
To the Editor-A recently published retrospective analysis by Matheson et al. [1] of zidovudine use during pregnancy suggests that antenatal zidovudine therapy may be responsible for a considerable amount ofzidovudine's protective effect in preventing vertical transmission of human immunodeficiency virus type 1 (HIV). Current Centers for Disease Control and Prevention guidelines suggest administ...
متن کاملZidovudine and perinatal human immunodeficiency virus type 1 transmission: a population-based approach.
OBJECTIVE This study examined the impact of the full 3-arm zidovudine regimen on the perinatal transmission of human immunodeficiency virus type 1 (HIV-1) using population-based data. METHODS We retrospectively ascertained information on zidovudine prescription and other characteristics of HIV-infected pregnant women and children for birth cohort years 1993, 1995, 1996, and 1997 using HIV/acq...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1991
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.35.2.305